HIV Nef, paxillin, and Pak1/2 regulate activation and secretion of TACE/ADAM10 proteases.

Lee, Jung-Hyun

HIV Nef, paxillin, and Pak1/2 regulate activation and secretion of TACE/ADAM10 proteases. [electronic resource] - Molecular cell Feb 2013 - 668-79 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1097-4164

10.1016/j.molcel.2012.12.004 doi


ADAM Proteins--blood
ADAM10 Protein
ADAM17 Protein
Adaptor Proteins, Signal Transducing--metabolism
Amino Acid Substitution
Amyloid Precursor Protein Secretases--blood
Case-Control Studies
Enzyme Activation
HEK293 Cells
HIV Infections--blood
Heterogeneous-Nuclear Ribonucleoprotein K
Humans
Melanoma--blood
Membrane Microdomains--enzymology
Membrane Proteins--blood
Mutagenesis, Site-Directed
Paxillin--genetics
Phosphorylation
Polycomb Repressive Complex 2--metabolism
Protein Binding
Protein Kinase C-delta--metabolism
Protein Precursors--metabolism
Protein Processing, Post-Translational
Protein Transport
Ribonucleoproteins--metabolism
Secretory Vesicles--metabolism
Signal Transduction
Tumor Cells, Cultured
Tumor Necrosis Factor-alpha--metabolism
nef Gene Products, Human Immunodeficiency Virus--metabolism
p21-Activated Kinases--metabolism