Loss and gain of Drosophila TDP-43 impair synaptic efficacy and motor control leading to age-related neurodegeneration by loss-of-function phenotypes.

Diaper, Danielle C

Loss and gain of Drosophila TDP-43 impair synaptic efficacy and motor control leading to age-related neurodegeneration by loss-of-function phenotypes. [electronic resource] - Human molecular genetics Apr 2013 - 1539-57 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1460-2083

10.1093/hmg/ddt005 doi


Aging
Amyotrophic Lateral Sclerosis--genetics
Animals
Animals, Genetically Modified
DNA-Binding Proteins--genetics
Disease Models, Animal
Drosophila melanogaster--genetics
Frontotemporal Lobar Degeneration--genetics
Larva
Nerve Degeneration--genetics
Neuromuscular Junction--metabolism
Neurons--metabolism
Phenotype
Synaptic Transmission--genetics