β1-Adrenoceptor autoantibodies from DCM patients enhance the proliferation of T lymphocytes through the β1-AR/cAMP/PKA and p38 MAPK pathways.

Du, Yunhui

β1-Adrenoceptor autoantibodies from DCM patients enhance the proliferation of T lymphocytes through the β1-AR/cAMP/PKA and p38 MAPK pathways. [electronic resource] - PloS one 2012 - e52911 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1932-6203

10.1371/journal.pone.0052911 doi


Adrenergic beta-1 Receptor Antagonists--pharmacology
Adrenergic beta-Agonists--pharmacology
Aged
Animals
Autoantibodies--blood
Cardiomyopathy, Dilated--immunology
Cell Proliferation--drug effects
Cyclic AMP-Dependent Protein Kinases--metabolism
Female
Humans
Imidazoles--pharmacology
Interferon-gamma--metabolism
Isoproterenol--pharmacology
Isoquinolines--pharmacology
Male
Metoprolol--pharmacology
Middle Aged
Phosphorylation--drug effects
Protein Kinase Inhibitors--pharmacology
Pyridines--pharmacology
Rats
Rats, Sprague-Dawley
Receptors, Adrenergic, beta-1--immunology
Signal Transduction--drug effects
Sulfonamides--pharmacology
T-Lymphocytes--drug effects
p38 Mitogen-Activated Protein Kinases--metabolism