Paeoniflorin attenuates amyloid-beta peptide-induced neurotoxicity by ameliorating oxidative stress and regulating the NGF-mediated signaling in rats.

Lan, Zhou

Paeoniflorin attenuates amyloid-beta peptide-induced neurotoxicity by ameliorating oxidative stress and regulating the NGF-mediated signaling in rats. [electronic resource] - Brain research Mar 2013 - 9-19 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1872-6240

10.1016/j.brainres.2012.12.040 doi


Acetylcholinesterase--metabolism
Amyloid beta-Peptides--toxicity
Animals
Catalase--metabolism
Choline O-Acetyltransferase--metabolism
Donepezil
Glucosides--chemistry
Hippocampus--drug effects
Indans--pharmacology
Male
Malondialdehyde--metabolism
Matrix Metalloproteinase 9--metabolism
Maze Learning--drug effects
Monoterpenes--chemistry
Nerve Growth Factor--metabolism
Neuroprotective Agents--chemistry
Nootropic Agents--pharmacology
Oxidative Stress--drug effects
Peptide Fragments--toxicity
Piperidines--pharmacology
Random Allocation
Rats, Sprague-Dawley
Receptor, trkA--metabolism
Spatial Memory--drug effects
Superoxide Dismutase--metabolism
Tissue Inhibitor of Metalloproteinase-1--metabolism