Identification of structural-kinetic and structural-thermodynamic relationships for thrombin inhibitors.

Winquist, Johan

Identification of structural-kinetic and structural-thermodynamic relationships for thrombin inhibitors. [electronic resource] - Biochemistry Jan 2013 - 613-26 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1520-4995

10.1021/bi301333z doi


Antithrombins--chemistry
Azetidines--chemistry
Benzylamines--chemistry
Catalytic Domain
Crystallography, X-Ray
Drug Discovery
Hirudins--chemistry
Humans
Hydrogen Bonding
Hydrophobic and Hydrophilic Interactions
Kinetics
Models, Molecular
Protein Binding
Surface Properties
Thermodynamics
Thrombin--antagonists & inhibitors