p42/p44-MAPK and PI3K are sufficient for IL-6 family cytokines/gp130 to signal to hypertrophy and survival in cardiomyocytes in the absence of JAK/STAT activation.

Fahmi, Ahmed

p42/p44-MAPK and PI3K are sufficient for IL-6 family cytokines/gp130 to signal to hypertrophy and survival in cardiomyocytes in the absence of JAK/STAT activation. [electronic resource] - Cellular signalling Apr 2013 - 898-909 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1873-3913

10.1016/j.cellsig.2012.12.008 doi


Animals
Cell Survival--drug effects
Cells, Cultured
Cytokine Receptor gp130--genetics
Flavonoids--pharmacology
Humans
Hypertrophy
Imidazoles--pharmacology
Interleukin-6--genetics
Janus Kinases--metabolism
Leukemia Inhibitory Factor--genetics
Mice
Mitogen-Activated Protein Kinase 1--antagonists & inhibitors
Mitogen-Activated Protein Kinase 3--antagonists & inhibitors
Myocytes, Cardiac--cytology
Nitric Oxide--metabolism
Nitric Oxide Synthase Type II--metabolism
Phosphatidylinositol 3-Kinases--metabolism
Phosphorylation
Pyridines--pharmacology
Rats
Receptors, Erythropoietin--genetics
Recombinant Fusion Proteins--genetics
Recombinant Proteins--biosynthesis
Reperfusion Injury--metabolism
STAT1 Transcription Factor--metabolism
STAT3 Transcription Factor--antagonists & inhibitors
Signal Transduction--drug effects
p38 Mitogen-Activated Protein Kinases--metabolism