Monotropein isolated from the roots of Morinda officinalis ameliorates proinflammatory mediators in RAW 264.7 macrophages and dextran sulfate sodium (DSS)-induced colitis via NF-κB inactivation.

Shin, Ji-Sun

Monotropein isolated from the roots of Morinda officinalis ameliorates proinflammatory mediators in RAW 264.7 macrophages and dextran sulfate sodium (DSS)-induced colitis via NF-κB inactivation. [electronic resource] - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association Mar 2013 - 263-71 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1873-6351

10.1016/j.fct.2012.12.013 doi


Animals
Anti-Inflammatory Agents--pharmacology
Cell Line, Tumor
Colitis--chemically induced
Cyclooxygenase 2--genetics
Dextran Sulfate--adverse effects
I-kappa B Proteins--genetics
Inflammation Mediators--antagonists & inhibitors
Interleukin-1beta--genetics
Iridoids--pharmacology
Lipopolysaccharides--adverse effects
Macrophages--drug effects
Mice
Morinda--chemistry
NF-KappaB Inhibitor alpha
NF-kappa B--antagonists & inhibitors
Nitric Oxide Synthase Type II--genetics
Peroxidase--metabolism
Phosphorylation
Plant Roots--chemistry
RNA, Messenger--genetics
Tumor Necrosis Factor-alpha--genetics