Cellular and molecular mechanisms underlie the anti-tumor activities exerted by Walterinnesia aegyptia venom combined with silica nanoparticles against multiple myeloma cancer cell types.
Badr, Gamal
Cellular and molecular mechanisms underlie the anti-tumor activities exerted by Walterinnesia aegyptia venom combined with silica nanoparticles against multiple myeloma cancer cell types. [electronic resource] - PloS one 2012 - e51661 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1932-6203
10.1371/journal.pone.0051661 doi
Actin Cytoskeleton--drug effects
Animals
Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Cell Line, Tumor
Cell Proliferation--drug effects
Cell Survival--drug effects
Chemokine CXCL12--pharmacology
Dose-Response Relationship, Drug
Down-Regulation--drug effects
Drug Screening Assays, Antitumor
Elapid Venoms--pharmacology
Elapidae--metabolism
Enzyme Activation--drug effects
Humans
Intercellular Adhesion Molecule-1--metabolism
Membrane Potential, Mitochondrial--drug effects
Multiple Myeloma--drug therapy
Nanoparticles--therapeutic use
Polymerization--drug effects
Proto-Oncogene Proteins c-bcl-2--metabolism
Receptors, CXCR4--metabolism
Silicon Dioxide--chemistry
Time Factors
Cellular and molecular mechanisms underlie the anti-tumor activities exerted by Walterinnesia aegyptia venom combined with silica nanoparticles against multiple myeloma cancer cell types. [electronic resource] - PloS one 2012 - e51661 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1932-6203
10.1371/journal.pone.0051661 doi
Actin Cytoskeleton--drug effects
Animals
Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Cell Line, Tumor
Cell Proliferation--drug effects
Cell Survival--drug effects
Chemokine CXCL12--pharmacology
Dose-Response Relationship, Drug
Down-Regulation--drug effects
Drug Screening Assays, Antitumor
Elapid Venoms--pharmacology
Elapidae--metabolism
Enzyme Activation--drug effects
Humans
Intercellular Adhesion Molecule-1--metabolism
Membrane Potential, Mitochondrial--drug effects
Multiple Myeloma--drug therapy
Nanoparticles--therapeutic use
Polymerization--drug effects
Proto-Oncogene Proteins c-bcl-2--metabolism
Receptors, CXCR4--metabolism
Silicon Dioxide--chemistry
Time Factors