Complement component 3 inhibition by an antioxidant is neuroprotective after cerebral ischemia and reperfusion in mice.

Yang, Jiwon

Complement component 3 inhibition by an antioxidant is neuroprotective after cerebral ischemia and reperfusion in mice. [electronic resource] - Journal of neurochemistry Feb 2013 - 523-35 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1471-4159

10.1111/jnc.12111 doi


Animals
Brain--drug effects
Brain Ischemia--blood
Cell Survival--drug effects
Cells, Cultured
Cerebral Cortex--cytology
Complement C3--genetics
Cyclic N-Oxides--therapeutic use
Cyclooxygenase 2--metabolism
Disease Models, Animal
Down-Regulation--drug effects
Enzyme-Linked Immunosorbent Assay
Glucose--deficiency
Hypoxia
L-Lactate Dehydrogenase--metabolism
Male
Mice
Mice, Transgenic
Nervous System Diseases--etiology
Neuroglia--drug effects
Neurons--drug effects
Neuroprotective Agents--therapeutic use
Oxidative Stress--drug effects
RNA, Messenger--metabolism
Reactive Oxygen Species--metabolism
Reperfusion Injury--prevention & control
Superoxide Dismutase--deficiency
Superoxide Dismutase-1
Time Factors
Up-Regulation--drug effects