Alzheimer's disease: presenilin 2-sparing γ-secretase inhibition is a tolerable Aβ peptide-lowering strategy.

Borgegård, Tomas

Alzheimer's disease: presenilin 2-sparing γ-secretase inhibition is a tolerable Aβ peptide-lowering strategy. [electronic resource] - The Journal of neuroscience : the official journal of the Society for Neuroscience Nov 2012 - 17297-305 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1529-2401

10.1523/JNEUROSCI.1451-12.2012 doi


Alzheimer Disease--drug therapy
Amyloid Precursor Protein Secretases--antagonists & inhibitors
Amyloid beta-Peptides--metabolism
Animals
Brain--drug effects
Mice
Presenilin-2--genetics
Receptors, Notch--genetics
Signal Transduction--drug effects
Sulfonamides--pharmacology