Slam haplotype 2 promotes NKT but suppresses Vγ4+ T-cell activation in coxsackievirus B3 infection leading to increased liver damage but reduced myocarditis.

Huber, Sally Ann

Slam haplotype 2 promotes NKT but suppresses Vγ4+ T-cell activation in coxsackievirus B3 infection leading to increased liver damage but reduced myocarditis. [electronic resource] - The American journal of pathology Feb 2013 - 401-9 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural

1525-2191

10.1016/j.ajpath.2012.10.019 doi


Adaptive Immunity--drug effects
Alanine Transaminase--blood
Animals
Antigens, CD--genetics
Coxsackievirus Infections--complications
Enterovirus B, Human--drug effects
Galactosylceramides--pharmacology
Haplotypes--genetics
Hepatitis--complications
Liver--immunology
Lymphocyte Activation--drug effects
Lymphocyte Count
Male
Mice
Mice, Inbred C57BL
Myocarditis--blood
Natural Killer T-Cells--drug effects
Polymorphism, Genetic
Receptors, Antigen, T-Cell, gamma-delta--immunology
Receptors, Cell Surface--genetics
Signaling Lymphocytic Activation Molecule Family Member 1
Troponin I--blood
Viral Load--immunology