Modification of a tumor antigen determinant to improve peptide/MHC stability is associated with increased immunogenicity and cross-priming a larger fraction of CD8+ T cells.

Watson, Alan M

Modification of a tumor antigen determinant to improve peptide/MHC stability is associated with increased immunogenicity and cross-priming a larger fraction of CD8+ T cells. [electronic resource] - Journal of immunology (Baltimore, Md. : 1950) Dec 2012 - 5549-60 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural

1550-6606

10.4049/jimmunol.1102221 doi


Animals
Antigens, Neoplasm--genetics
Antigens, Polyomavirus Transforming--genetics
CD8-Positive T-Lymphocytes--immunology
Cross-Priming--genetics
Epitopes, T-Lymphocyte--genetics
Lymphocyte Activation--genetics
Lymphocyte Count
Major Histocompatibility Complex--genetics
Mice
Mice, Inbred C57BL
Mice, Transgenic
Peptides--metabolism
Protein Stability
Simian virus 40--genetics
Tumor Cells, Cultured
Up-Regulation--genetics