Engineering a soluble high-affinity receptor domain that neutralizes staphylococcal enterotoxin C in rabbit models of disease.

Mattis, D M

Engineering a soluble high-affinity receptor domain that neutralizes staphylococcal enterotoxin C in rabbit models of disease. [electronic resource] - Protein engineering, design & selection : PEDS Feb 2013 - 133-42 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1741-0134

10.1093/protein/gzs094 doi


Animals
Anti-Bacterial Agents--administration & dosage
Cell Line
Cell Surface Display Techniques
Directed Molecular Evolution
Disease Models, Animal
Endocarditis, Bacterial--drug therapy
Enterotoxins--antagonists & inhibitors
Humans
Interleukin-2--metabolism
Lymphocyte Activation
Methicillin-Resistant Staphylococcus aureus--immunology
Pneumonia, Staphylococcal--drug therapy
Protein Binding
Protein Engineering
Rabbits
Receptors, Antigen, T-Cell, alpha-beta--administration & dosage
Recombinant Proteins--administration & dosage
Staphylococcal Infections--drug therapy
Superantigens--metabolism
T-Lymphocytes--drug effects