Increased selectivity toward cytoplasmic versus mitochondrial ribosome confers improved efficiency of synthetic aminoglycosides in fixing damaged genes: a strategy for treatment of genetic diseases caused by nonsense mutations.

Kandasamy, Jeyakumar

Increased selectivity toward cytoplasmic versus mitochondrial ribosome confers improved efficiency of synthetic aminoglycosides in fixing damaged genes: a strategy for treatment of genetic diseases caused by nonsense mutations. [electronic resource] - Journal of medicinal chemistry Dec 2012 - 10630-43 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1520-4804

10.1021/jm3012992 doi


Aminoglycosides--pharmacology
Codon, Nonsense
Cytoplasm--drug effects
Genetic Diseases, Inborn--therapy
Humans
Magnetic Resonance Spectroscopy
Mitochondria--drug effects
Ribosomes--drug effects
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization