Alterations in endocannabinoid tone following chemotherapy-induced peripheral neuropathy: effects of endocannabinoid deactivation inhibitors targeting fatty-acid amide hydrolase and monoacylglycerol lipase in comparison to reference analgesics following cisplatin treatment.

Guindon, Josée

Alterations in endocannabinoid tone following chemotherapy-induced peripheral neuropathy: effects of endocannabinoid deactivation inhibitors targeting fatty-acid amide hydrolase and monoacylglycerol lipase in comparison to reference analgesics following cisplatin treatment. [electronic resource] - Pharmacological research Jan 2013 - 94-109 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural

1096-1186

10.1016/j.phrs.2012.10.013 doi


Amidohydrolases--antagonists & inhibitors
Analgesics--pharmacology
Animals
Antineoplastic Agents--adverse effects
Arachidonic Acids--metabolism
Benzamides--pharmacology
Benzodioxoles--pharmacology
Cannabinoids--pharmacology
Carbamates--pharmacology
Cisplatin--adverse effects
Endocannabinoids--metabolism
Enzyme Inhibitors--pharmacology
Ganglia, Spinal--drug effects
Glycerides--metabolism
Hyperalgesia--drug therapy
Lipid Metabolism--drug effects
Male
Monoacylglycerol Lipases--antagonists & inhibitors
Peripheral Nervous System Diseases--chemically induced
Piperidines--pharmacology
Polyunsaturated Alkamides--metabolism
RNA, Messenger--metabolism
Rats
Rats, Sprague-Dawley
Receptor, Cannabinoid, CB1--genetics
Receptor, Cannabinoid, CB2--genetics
Spinal Cord--drug effects
TRPV Cation Channels--genetics