BET bromodomain proteins mediate downstream signaling events following growth factor stimulation in human lung fibroblasts and are involved in bleomycin-induced pulmonary fibrosis.

Tang, Xiaoyan

BET bromodomain proteins mediate downstream signaling events following growth factor stimulation in human lung fibroblasts and are involved in bleomycin-induced pulmonary fibrosis. [electronic resource] - Molecular pharmacology Jan 2013 - 283-93 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1521-0111

10.1124/mol.112.081661 doi


Actins--biosynthesis
Administration, Oral
Animals
Becaplermin
Bleomycin
Cell Cycle Proteins
Cell Movement
Cell Proliferation
Cytokines--metabolism
Epigenesis, Genetic
Extracellular Matrix Proteins--biosynthesis
Fibroblasts--drug effects
Humans
Lung--drug effects
Male
Mice
Mice, Inbred C57BL
Nuclear Proteins--antagonists & inhibitors
Protein Serine-Threonine Kinases--antagonists & inhibitors
Proto-Oncogene Proteins c-sis--metabolism
Pulmonary Fibrosis--chemically induced
RNA, Small Interfering--genetics
Transcription Factors--antagonists & inhibitors
Transcription, Genetic
Transforming Growth Factor beta1--metabolism