Reduced PDZ interactions of rescued ΔF508CFTR increases its cell surface mobility.

Valentine, Cathleen D

Reduced PDZ interactions of rescued ΔF508CFTR increases its cell surface mobility. [electronic resource] - The Journal of biological chemistry Dec 2012 - 43630-8 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1083-351X

10.1074/jbc.M112.421172 doi


Amino Acid Sequence
Animals
Cell Movement--physiology
Cystic Fibrosis Transmembrane Conductance Regulator--genetics
Dogs
Endocytosis--physiology
Gene Knockdown Techniques
HSC70 Heat-Shock Proteins--genetics
HeLa Cells
Humans
Lysosomes--genetics
Protein Structure, Tertiary
Proteolysis
Sequence Deletion
Ubiquitin-Protein Ligases--genetics
Ubiquitination--physiology