Intrinsic caspase-8 activation mediates sensitization of erlotinib-resistant tumor cells to erlotinib/cell-cycle inhibitors combination treatment.

Orzáez, M

Intrinsic caspase-8 activation mediates sensitization of erlotinib-resistant tumor cells to erlotinib/cell-cycle inhibitors combination treatment. [electronic resource] - Cell death & disease Oct 2012 - e415 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

2041-4889

10.1038/cddis.2012.155 doi


Antineoplastic Combined Chemotherapy Protocols--pharmacology
Apoptosis--drug effects
Caspase 8--genetics
Cell Cycle--drug effects
Cell Line, Tumor
Cell Survival--drug effects
Cyclin A--antagonists & inhibitors
Cyclin-Dependent Kinase 2--antagonists & inhibitors
Drug Resistance, Neoplasm--drug effects
Drug Therapy, Combination
Erlotinib Hydrochloride
Humans
Neoplasms--drug therapy
Quinazolines--pharmacology