Inhibition of rho kinase enhances survival of dopaminergic neurons and attenuates axonal loss in a mouse model of Parkinson's disease.

Tönges, Lars

Inhibition of rho kinase enhances survival of dopaminergic neurons and attenuates axonal loss in a mouse model of Parkinson's disease. [electronic resource] - Brain : a journal of neurology Nov 2012 - 3355-70 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1460-2156

10.1093/brain/aws254 doi


1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine--analogs & derivatives
1-Methyl-4-phenylpyridinium--toxicity
Animals
Axons--drug effects
Behavior, Animal--drug effects
Cell Survival--drug effects
Cells, Cultured
Corpus Striatum--metabolism
Disease Models, Animal
Dopamine--metabolism
Dopaminergic Neurons--enzymology
MPTP Poisoning--drug therapy
Male
Mice
Mice, Inbred C57BL
Nerve Degeneration--chemically induced
Neurites--pathology
Neuroprotective Agents--metabolism
Parkinson Disease, Secondary--chemically induced
Proto-Oncogene Proteins c-akt--drug effects
Rats
Rats, Wistar
Substantia Nigra--drug effects
rho-Associated Kinases--antagonists & inhibitors