Nitrogen-containing bisphosphonates induce apoptosis of hematopoietic tumor cells via inhibition of Ras signaling pathways and Bim-mediated activation of the intrinsic apoptotic pathway.
Tsubaki, Masanobu
Nitrogen-containing bisphosphonates induce apoptosis of hematopoietic tumor cells via inhibition of Ras signaling pathways and Bim-mediated activation of the intrinsic apoptotic pathway. [electronic resource] - Biochemical pharmacology Jan 2013 - 163-72 p. digital
Publication Type: Journal Article
1873-2968
10.1016/j.bcp.2012.10.009 doi
Alendronate--adverse effects
Antineoplastic Agents--adverse effects
Apoptosis--drug effects
Apoptosis Regulatory Proteins--antagonists & inhibitors
Bcl-2-Like Protein 11
Bone Density Conservation Agents--adverse effects
Cell Line, Tumor
Cell Nucleus--drug effects
Cell Survival--drug effects
Diphosphonates--adverse effects
Gene Expression Regulation, Neoplastic--drug effects
Gene Silencing
Hematologic Neoplasms--drug therapy
Humans
Imidazoles--adverse effects
MAP Kinase Signaling System--drug effects
Membrane Proteins--antagonists & inhibitors
Neoplasm Proteins--antagonists & inhibitors
Protein Kinase Inhibitors--pharmacology
Protein Prenylation--drug effects
Proto-Oncogene Proteins--antagonists & inhibitors
Proto-Oncogene Proteins p21(ras)--antagonists & inhibitors
Signal Transduction--drug effects
TOR Serine-Threonine Kinases--antagonists & inhibitors
Nitrogen-containing bisphosphonates induce apoptosis of hematopoietic tumor cells via inhibition of Ras signaling pathways and Bim-mediated activation of the intrinsic apoptotic pathway. [electronic resource] - Biochemical pharmacology Jan 2013 - 163-72 p. digital
Publication Type: Journal Article
1873-2968
10.1016/j.bcp.2012.10.009 doi
Alendronate--adverse effects
Antineoplastic Agents--adverse effects
Apoptosis--drug effects
Apoptosis Regulatory Proteins--antagonists & inhibitors
Bcl-2-Like Protein 11
Bone Density Conservation Agents--adverse effects
Cell Line, Tumor
Cell Nucleus--drug effects
Cell Survival--drug effects
Diphosphonates--adverse effects
Gene Expression Regulation, Neoplastic--drug effects
Gene Silencing
Hematologic Neoplasms--drug therapy
Humans
Imidazoles--adverse effects
MAP Kinase Signaling System--drug effects
Membrane Proteins--antagonists & inhibitors
Neoplasm Proteins--antagonists & inhibitors
Protein Kinase Inhibitors--pharmacology
Protein Prenylation--drug effects
Proto-Oncogene Proteins--antagonists & inhibitors
Proto-Oncogene Proteins p21(ras)--antagonists & inhibitors
Signal Transduction--drug effects
TOR Serine-Threonine Kinases--antagonists & inhibitors