Yokukansan inhibits morphine tolerance and physical dependence in mice: the role of α₂A-adrenoceptor.

Nakagawa, T

Yokukansan inhibits morphine tolerance and physical dependence in mice: the role of α₂A-adrenoceptor. [electronic resource] - Neuroscience Dec 2012 - 336-49 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1873-7544

10.1016/j.neuroscience.2012.09.079 doi


Adrenergic Agents--pharmacology
Adrenergic alpha-Antagonists--pharmacokinetics
Adrenergic beta-Antagonists--pharmacology
Analysis of Variance
Animals
Behavior, Addictive--drug therapy
Disease Models, Animal
Dose-Response Relationship, Drug
Drug Tolerance
Drugs, Chinese Herbal--therapeutic use
Guanosine 5'-O-(3-Thiotriphosphate)--pharmacokinetics
Guanosine Diphosphate--pharmacology
Isotopes--pharmacokinetics
Male
Mice
Morphine Dependence--drug therapy
Norepinephrine Plasma Membrane Transport Proteins--metabolism
Pain Threshold--drug effects
Propranolol--pharmacology
Protein Binding--drug effects
Radioligand Assay
Receptors, Adrenergic, alpha-2--metabolism
Time Factors
Tropanes--pharmacokinetics