PSGL-1/selectin and ICAM-1/CD18 interactions are involved in macrophage-induced drug resistance in myeloma.

Zheng, Y

PSGL-1/selectin and ICAM-1/CD18 interactions are involved in macrophage-induced drug resistance in myeloma. [electronic resource] - Leukemia Mar 2013 - 702-10 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1476-5551

10.1038/leu.2012.272 doi


Animals
Antineoplastic Agents, Alkylating--pharmacology
Apoptosis--drug effects
Blotting, Western
Bone Marrow--drug effects
CD18 Antigens--genetics
Cell Proliferation--drug effects
Drug Resistance, Neoplasm
Female
Flow Cytometry
Humans
Immunoenzyme Techniques
Immunoprecipitation
Intercellular Adhesion Molecule-1--genetics
Macrophages--drug effects
Melphalan--pharmacology
Membrane Glycoproteins--genetics
Mice
Mice, SCID
Multiple Myeloma--drug therapy
P-Selectin--genetics
RNA, Messenger--genetics
Real-Time Polymerase Chain Reaction
Reverse Transcriptase Polymerase Chain Reaction
Tumor Cells, Cultured
Tumor Microenvironment