Kinetic modeling of human hepatic glucose metabolism in type 2 diabetes mellitus predicts higher risk of hypoglycemic events in rigorous insulin therapy.

König, Matthias

Kinetic modeling of human hepatic glucose metabolism in type 2 diabetes mellitus predicts higher risk of hypoglycemic events in rigorous insulin therapy. [electronic resource] - The Journal of biological chemistry Oct 2012 - 36978-89 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1083-351X

10.1074/jbc.M112.382069 doi


Algorithms
Blood Glucose
Carbohydrate Metabolism
Computer Simulation
Diabetes Mellitus, Type 2--blood
Epinephrine--blood
Glucagon--blood
Glucose--metabolism
Glycogen--metabolism
Hepatocytes--metabolism
Humans
Hypoglycemia--blood
Hypoglycemic Agents--adverse effects
Insulin--adverse effects
Insulin Resistance
Kinetics
Liver--cytology
Models, Biological
Phosphorylation
Postprandial Period
Protein Processing, Post-Translational