Vildagliptin preserves the mass and function of pancreatic β cells via the developmental regulation and suppression of oxidative and endoplasmic reticulum stress in a mouse model of diabetes.

Hamamoto, S

Vildagliptin preserves the mass and function of pancreatic β cells via the developmental regulation and suppression of oxidative and endoplasmic reticulum stress in a mouse model of diabetes. [electronic resource] - Diabetes, obesity & metabolism Feb 2013 - 153-63 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1463-1326

10.1111/dom.12005 doi


Adamantane--analogs & derivatives
Animals
Apoptosis
Blood Glucose--metabolism
Cell Proliferation
Diabetes Mellitus, Experimental--drug therapy
Endoplasmic Reticulum Stress--drug effects
Gene Expression Regulation, Developmental
Immunohistochemistry
Insulin--metabolism
Insulin-Secreting Cells--metabolism
Male
Mice
Mice, Inbred C57BL
Nitriles--pharmacology
Oxidative Stress--drug effects
Pyrrolidines--pharmacology
Real-Time Polymerase Chain Reaction
Triglycerides--metabolism
Up-Regulation
Vildagliptin