Generation and characterization of novel cytochrome P450 Cyp2c gene cluster knockout and CYP2C9 humanized mouse lines.

Scheer, Nico

Generation and characterization of novel cytochrome P450 Cyp2c gene cluster knockout and CYP2C9 humanized mouse lines. [electronic resource] - Molecular pharmacology Dec 2012 - 1022-9 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1521-0111

10.1124/mol.112.080036 doi


Animals
Aryl Hydrocarbon Hydroxylases--genetics
Cytochrome P-450 CYP2C9
Cytochrome P-450 Enzyme Inhibitors
Cytochrome P-450 Enzyme System--genetics
Humans
Hydroxylation
Inactivation, Metabolic
Liver--drug effects
Mice
Mice, Inbred C57BL
Mice, Knockout
Multigene Family--drug effects
Tolbutamide--metabolism