Alzheimer's β-secretase (BACE1) regulates the cAMP/PKA/CREB pathway independently of β-amyloid.

Chen, Yaomin

Alzheimer's β-secretase (BACE1) regulates the cAMP/PKA/CREB pathway independently of β-amyloid. [electronic resource] - The Journal of neuroscience : the official journal of the Society for Neuroscience Aug 2012 - 11390-5 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1529-2401

10.1523/JNEUROSCI.0757-12.2012 doi


Amyloid Precursor Protein Secretases--genetics
Amyloid beta-Peptides--metabolism
Amyloid beta-Protein Precursor--deficiency
Animals
Aspartic Acid Endopeptidases--genetics
Brain--cytology
CREB-Binding Protein--metabolism
Cells, Cultured
Colforsin--pharmacology
Cyclic AMP--metabolism
Cyclic AMP-Dependent Protein Kinases--metabolism
Disks Large Homolog 4 Protein
Embryo, Mammalian
Gene Expression Regulation--drug effects
Green Fluorescent Proteins--genetics
Guanylate Kinases--metabolism
MARVEL Domain-Containing Proteins
Membrane Proteins--deficiency
Mice
Mice, Inbred C57BL
Mice, Transgenic
Mutation--genetics
Neuroblastoma--pathology
Phosphorylation--drug effects
Proteolipids
Signal Transduction--physiology
Synaptophysin--metabolism
Transfection