Development of novel bisphosphonate prodrugs of doxorubicin for targeting bone metastases that are cleaved pH dependently or by cathepsin B: synthesis, cleavage properties, and binding properties to hydroxyapatite as well as bone matrix.

Hochdörffer, Katrin

Development of novel bisphosphonate prodrugs of doxorubicin for targeting bone metastases that are cleaved pH dependently or by cathepsin B: synthesis, cleavage properties, and binding properties to hydroxyapatite as well as bone matrix. [electronic resource] - Journal of medicinal chemistry Sep 2012 - 7502-15 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1520-4804

10.1021/jm300493m doi


Bone Neoplasms--drug therapy
Bone and Bones--metabolism
Cathepsin B--metabolism
Diphosphonates--metabolism
Doxorubicin--metabolism
Durapatite--metabolism
Humans
Hydrogen-Ion Concentration
Prodrugs--metabolism