Highly pathogenic Alzheimer's disease presenilin 1 P117R mutation causes a specific increase in p53 and p21 protein levels and cell cycle dysregulation in human lymphocytes.

Bialopiotrowicz, Emilia

Highly pathogenic Alzheimer's disease presenilin 1 P117R mutation causes a specific increase in p53 and p21 protein levels and cell cycle dysregulation in human lymphocytes. [electronic resource] - Journal of Alzheimer's disease : JAD 2012 - 397-415 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1875-8908

10.3233/JAD-2012-121129 doi


Adult
Alzheimer Disease--genetics
Apoptosis--genetics
B-Lymphocytes--metabolism
Cell Cycle--genetics
Cyclin-Dependent Kinase Inhibitor p21--genetics
Female
HEK293 Cells
Humans
Male
Middle Aged
Mutation
Presenilin-1--genetics
Tumor Suppressor Protein p53--genetics