Structural characteristics determine the cause of the low enzyme activity of two thiopurine S-methyltransferase allelic variants: a biophysical characterization of TPMT*2 and TPMT*5.
Wennerstrand, Patricia
Structural characteristics determine the cause of the low enzyme activity of two thiopurine S-methyltransferase allelic variants: a biophysical characterization of TPMT*2 and TPMT*5. [electronic resource] - Biochemistry Jul 2012 - 5912-20 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1520-4995
10.1021/bi300377d doi
Alleles
Amino Acid Sequence
Catalytic Domain--genetics
Enzyme Activation--genetics
Genetic Variation--genetics
Humans
Methyltransferases--chemistry
Molecular Sequence Data
Structural characteristics determine the cause of the low enzyme activity of two thiopurine S-methyltransferase allelic variants: a biophysical characterization of TPMT*2 and TPMT*5. [electronic resource] - Biochemistry Jul 2012 - 5912-20 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1520-4995
10.1021/bi300377d doi
Alleles
Amino Acid Sequence
Catalytic Domain--genetics
Enzyme Activation--genetics
Genetic Variation--genetics
Humans
Methyltransferases--chemistry
Molecular Sequence Data