Minocycline blocks lipopolysaccharide induced hyperalgesia by suppression of microglia but not astrocytes.

Yoon, S-Y

Minocycline blocks lipopolysaccharide induced hyperalgesia by suppression of microglia but not astrocytes. [electronic resource] - Neuroscience Sep 2012 - 214-24 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural

1873-7544

10.1016/j.neuroscience.2012.06.024 doi


Analgesics--therapeutic use
Analysis of Variance
Animals
Astrocytes--drug effects
Body Temperature--drug effects
Calcium-Binding Proteins--metabolism
Cytokines--genetics
Ectodysplasins--metabolism
Ganglia, Spinal--drug effects
Gene Expression Regulation--drug effects
Glial Fibrillary Acidic Protein--metabolism
Hyperalgesia--chemically induced
Lipopolysaccharides--adverse effects
Male
Microfilament Proteins--metabolism
Microglia--drug effects
Minocycline--therapeutic use
Pain Measurement
Pain Threshold--drug effects
Physical Stimulation
RNA, Messenger--metabolism
Rats
Rats, Sprague-Dawley
Reaction Time--drug effects
Seizures, Febrile--chemically induced
Spinal Cord--drug effects
Time Factors