Early rapid identification of in vivo rat metabolites of AN6414, a novel boron-containing PDE4 inhibitor by QTRAP LC/MS/MS to support drug discovery.

Bu, Wei

Early rapid identification of in vivo rat metabolites of AN6414, a novel boron-containing PDE4 inhibitor by QTRAP LC/MS/MS to support drug discovery. [electronic resource] - Journal of pharmaceutical and biomedical analysis Nov 2012 - 344-53 p. digital

Publication Type: Journal Article

1873-264X

10.1016/j.jpba.2012.05.024 doi


Administration, Oral
Animals
Anti-Inflammatory Agents--administration & dosage
Area Under Curve
Biotransformation
Boron Compounds--administration & dosage
Chromatography, Liquid
Drug Discovery--methods
Female
Male
Metabolic Clearance Rate
Models, Biological
Oxidation-Reduction
Phosphodiesterase 4 Inhibitors--administration & dosage
Pyridines--administration & dosage
Rats
Rats, Sprague-Dawley
Risk Assessment
Software
Solid Phase Extraction
Sulfates--pharmacokinetics
Tandem Mass Spectrometry