Use of mechanistic modeling to assess interindividual variability and interspecies differences in active uptake in human and rat hepatocytes.
Ménochet, Karelle
Use of mechanistic modeling to assess interindividual variability and interspecies differences in active uptake in human and rat hepatocytes. [electronic resource] - Drug metabolism and disposition: the biological fate of chemicals Sep 2012 - 1744-56 p. digital
Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
1521-009X
10.1124/dmd.112.046193 doi
Angiotensin II Type 1 Receptor Blockers--metabolism
Animals
Antihypertensive Agents--metabolism
Benzimidazoles--metabolism
Benzoates--metabolism
Biological Transport
Bosentan
Carbamates--metabolism
Dose-Response Relationship, Drug
Drug Interactions
Fluorobenzenes--metabolism
Hepatocytes--drug effects
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors--metabolism
Hypoglycemic Agents--metabolism
Kinetics
Models, Biological
Organic Anion Transporters--drug effects
Piperidines--metabolism
Pravastatin--metabolism
Pyrimidines--metabolism
Quinolines--metabolism
Rats
Rosuvastatin Calcium
Species Specificity
Sulfonamides--metabolism
Telmisartan
Tetrazoles--metabolism
Valine--analogs & derivatives
Valsartan
Use of mechanistic modeling to assess interindividual variability and interspecies differences in active uptake in human and rat hepatocytes. [electronic resource] - Drug metabolism and disposition: the biological fate of chemicals Sep 2012 - 1744-56 p. digital
Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
1521-009X
10.1124/dmd.112.046193 doi
Angiotensin II Type 1 Receptor Blockers--metabolism
Animals
Antihypertensive Agents--metabolism
Benzimidazoles--metabolism
Benzoates--metabolism
Biological Transport
Bosentan
Carbamates--metabolism
Dose-Response Relationship, Drug
Drug Interactions
Fluorobenzenes--metabolism
Hepatocytes--drug effects
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors--metabolism
Hypoglycemic Agents--metabolism
Kinetics
Models, Biological
Organic Anion Transporters--drug effects
Piperidines--metabolism
Pravastatin--metabolism
Pyrimidines--metabolism
Quinolines--metabolism
Rats
Rosuvastatin Calcium
Species Specificity
Sulfonamides--metabolism
Telmisartan
Tetrazoles--metabolism
Valine--analogs & derivatives
Valsartan