Slipping pumps or proton leaks in oxidative phosphorylation. The local anesthetic bupivacaine causes slip in cytochrome c oxidase of mitochondria.

van Dam, K

Slipping pumps or proton leaks in oxidative phosphorylation. The local anesthetic bupivacaine causes slip in cytochrome c oxidase of mitochondria. [electronic resource] - FEBS letters Dec 1990 - 131-3 p. digital

Publication Type: Journal Article

0014-5793

10.1016/0014-5793(90)80826-5 doi


Anilino Naphthalenesulfonates--pharmacology
Animals
Bupivacaine--pharmacology
Electron Transport Complex IV--metabolism
Hydrogen-Ion Concentration
Male
Mitochondria, Liver--drug effects
Oxidative Phosphorylation--drug effects
Oxygen Consumption--drug effects
Proton-Translocating ATPases--metabolism
Rats
Rats, Inbred Strains