Interferon-β therapy against EAE is effective only when development of the disease depends on the NLRP3 inflammasome.
Inoue, Makoto
Interferon-β therapy against EAE is effective only when development of the disease depends on the NLRP3 inflammasome. [electronic resource] - Science signaling May 2012 - ra38 p. digital
Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1937-9145
10.1126/scisignal.2002767 doi
Animals
Apoptosis Regulatory Proteins
CARD Signaling Adaptor Proteins
CD4-Positive T-Lymphocytes--transplantation
Carrier Proteins--genetics
Caspase 1--physiology
Cytoskeletal Proteins--deficiency
Disease Models, Animal
Encephalomyelitis, Autoimmune, Experimental--drug therapy
Enzyme Activation
Gene Expression Regulation--drug effects
Inflammasomes--physiology
Interferon beta-1b
Interferon-beta--therapeutic use
Interleukin-1beta--biosynthesis
Macrophages--physiology
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Mice, Transgenic
NLR Family, Pyrin Domain-Containing 3 Protein
Neuropeptides--antagonists & inhibitors
Proto-Oncogene Proteins c-vav--antagonists & inhibitors
Reactive Oxygen Species--metabolism
Receptor, Interferon alpha-beta--deficiency
Recombinant Proteins--therapeutic use
Suppressor of Cytokine Signaling 1 Protein
Suppressor of Cytokine Signaling Proteins--antagonists & inhibitors
rac GTP-Binding Proteins--antagonists & inhibitors
rac1 GTP-Binding Protein
Interferon-β therapy against EAE is effective only when development of the disease depends on the NLRP3 inflammasome. [electronic resource] - Science signaling May 2012 - ra38 p. digital
Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1937-9145
10.1126/scisignal.2002767 doi
Animals
Apoptosis Regulatory Proteins
CARD Signaling Adaptor Proteins
CD4-Positive T-Lymphocytes--transplantation
Carrier Proteins--genetics
Caspase 1--physiology
Cytoskeletal Proteins--deficiency
Disease Models, Animal
Encephalomyelitis, Autoimmune, Experimental--drug therapy
Enzyme Activation
Gene Expression Regulation--drug effects
Inflammasomes--physiology
Interferon beta-1b
Interferon-beta--therapeutic use
Interleukin-1beta--biosynthesis
Macrophages--physiology
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Mice, Transgenic
NLR Family, Pyrin Domain-Containing 3 Protein
Neuropeptides--antagonists & inhibitors
Proto-Oncogene Proteins c-vav--antagonists & inhibitors
Reactive Oxygen Species--metabolism
Receptor, Interferon alpha-beta--deficiency
Recombinant Proteins--therapeutic use
Suppressor of Cytokine Signaling 1 Protein
Suppressor of Cytokine Signaling Proteins--antagonists & inhibitors
rac GTP-Binding Proteins--antagonists & inhibitors
rac1 GTP-Binding Protein