zVAD-fmk upregulates caspase-9 cleavage and activity in etoposide-induced cell death of mouse embryonic fibroblasts.

Rodríguez-Enfedaque, Aida

zVAD-fmk upregulates caspase-9 cleavage and activity in etoposide-induced cell death of mouse embryonic fibroblasts. [electronic resource] - Biochimica et biophysica acta Aug 2012 - 1343-52 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0006-3002

10.1016/j.bbamcr.2012.05.013 doi


Amino Acid Chloromethyl Ketones--pharmacology
Animals
Antineoplastic Agents, Phytogenic--pharmacology
Apoptosis--drug effects
Caspase 3--metabolism
Caspase 6--metabolism
Caspase 9--metabolism
Caspase Inhibitors--pharmacology
Cells, Cultured
Cytochromes c--metabolism
Drug Synergism
Embryo, Mammalian
Enzyme Activation--drug effects
Etoposide--pharmacology
Fibroblasts
Membrane Potential, Mitochondrial--drug effects
Mice
Tumor Suppressor Protein p53--metabolism
Up-Regulation
bcl-2 Homologous Antagonist-Killer Protein--metabolism
bcl-2-Associated X Protein--metabolism