Nitric oxide-dependent CYP2B degradation is potentiated by a cytokine-regulated pathway and utilizes the immunoproteasome subunit LMP2.

Sun, Haiyan

Nitric oxide-dependent CYP2B degradation is potentiated by a cytokine-regulated pathway and utilizes the immunoproteasome subunit LMP2. [electronic resource] - The Biochemical journal Aug 2012 - 377-82 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1470-8728

10.1042/BJ20120820 doi


Animals
Aryl Hydrocarbon Hydroxylases--metabolism
Cysteine Endopeptidases--metabolism
Cytochrome P-450 CYP2B1--metabolism
Genes, Tumor Suppressor
Hepatocytes--drug effects
In Vitro Techniques
Interleukin-1--pharmacology
Kinetics
Male
Metabolic Networks and Pathways
Models, Biological
NG-Nitroarginine Methyl Ester--pharmacology
Nitric Oxide--metabolism
Nitric Oxide Donors--pharmacology
Nitric Oxide Synthase Type II--antagonists & inhibitors
Nuclear Proteins
Proteasome Endopeptidase Complex--metabolism
Proteasome Inhibitors
Rats
Rats, Inbred F344
Steroid Hydroxylases--metabolism