Securin enhances the anti-cancer effects of 6-methoxy-3-(3',4',5'-trimethoxy-benzoyl)-1H-indole (BPR0L075) in human colorectal cancer cells.

Tseng, Ho-Hsing

Securin enhances the anti-cancer effects of 6-methoxy-3-(3',4',5'-trimethoxy-benzoyl)-1H-indole (BPR0L075) in human colorectal cancer cells. [electronic resource] - PloS one 2012 - e36006 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1932-6203

10.1371/journal.pone.0036006 doi


Antineoplastic Agents--pharmacology
Apoptosis--drug effects
CDC2 Protein Kinase--metabolism
Caspases--metabolism
Colorectal Neoplasms--metabolism
DNA Repair--drug effects
G2 Phase Cell Cycle Checkpoints--drug effects
HCT116 Cells
Humans
Indoles--pharmacology
JNK Mitogen-Activated Protein Kinases--metabolism
M Phase Cell Cycle Checkpoints--drug effects
Neoplasm Proteins--genetics
Phosphorylation--drug effects
Securin
p38 Mitogen-Activated Protein Kinases--metabolism