Discovery of a novel series of potent and orally bioavailable phosphoinositide 3-kinase γ inhibitors.

Leahy, James W

Discovery of a novel series of potent and orally bioavailable phosphoinositide 3-kinase γ inhibitors. [electronic resource] - Journal of medicinal chemistry Jun 2012 - 5467-82 p. digital

Publication Type: Journal Article

1520-4804

10.1021/jm300403a doi


Administration, Oral
Animals
Biological Availability
Cell Line
Crystallography, X-Ray
Female
High-Throughput Screening Assays
Humans
Isoenzymes--antagonists & inhibitors
Luminescent Measurements
Mice
Microsomes, Liver--metabolism
Models, Molecular
Molecular Structure
Phosphoinositide-3 Kinase Inhibitors
Phosphorylation
Piperazines--chemical synthesis
Proto-Oncogene Proteins c-akt--metabolism
Rats
Rats, Sprague-Dawley
Structure-Activity Relationship
Sulfonamides--chemical synthesis
Sulfones--chemical synthesis