Polythiophenes inhibit prion propagation by stabilizing prion protein (PrP) aggregates.

Margalith, Ilan

Polythiophenes inhibit prion propagation by stabilizing prion protein (PrP) aggregates. [electronic resource] - The Journal of biological chemistry Jun 2012 - 18872-87 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1083-351X

10.1074/jbc.M112.355958 doi


Animals
Cerebellum--metabolism
Mice
Peptide Fragments--metabolism
Polymers--pharmacology
PrPSc Proteins--metabolism
Prions--metabolism
Protein Stability--drug effects
Protein Structure, Tertiary
Proteolysis--drug effects
Thiophenes--pharmacology