Systemic proteasome inhibition triggers neurodegeneration in a transgenic mouse model expressing human α-synuclein under oligodendrocyte promoter: implications for multiple system atrophy.

Stefanova, Nadia

Systemic proteasome inhibition triggers neurodegeneration in a transgenic mouse model expressing human α-synuclein under oligodendrocyte promoter: implications for multiple system atrophy. [electronic resource] - Acta neuropathologica Jul 2012 - 51-65 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1432-0533

10.1007/s00401-012-0977-5 doi


2',3'-Cyclic-Nucleotide Phosphodiesterases--metabolism
Analysis of Variance
Animals
Autophagy--drug effects
Brain--drug effects
Dopamine and cAMP-Regulated Phosphoprotein 32--metabolism
Exploratory Behavior--drug effects
Humans
Mice
Mice, Inbred C57BL
Mice, Transgenic
Microscopy, Immunoelectron
Motor Activity--drug effects
Myelin Proteolipid Protein--genetics
Neurodegenerative Diseases--chemically induced
Oligodendroglia--drug effects
Oligopeptides--toxicity
Proteasome Endopeptidase Complex--metabolism
Time Factors
Tyrosine 3-Monooxygenase
Ubiquitin--metabolism
alpha-Synuclein--genetics