Multicenter randomized phase II clinical trial comparing neoadjuvant oxaliplatin, capecitabine, and preoperative radiotherapy with or without cetuximab followed by total mesorectal excision in patients with high-risk rectal cancer (EXPERT-C).

Dewdney, Alice

Multicenter randomized phase II clinical trial comparing neoadjuvant oxaliplatin, capecitabine, and preoperative radiotherapy with or without cetuximab followed by total mesorectal excision in patients with high-risk rectal cancer (EXPERT-C). [electronic resource] - Journal of clinical oncology : official journal of the American Society of Clinical Oncology May 2012 - 1620-7 p. digital

Publication Type: Clinical Trial, Phase II; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't

1527-7755

10.1200/JCO.2011.39.6036 doi


Adenocarcinoma--mortality
Adult
Aged
Analysis of Variance
Antibodies, Monoclonal--administration & dosage
Antibodies, Monoclonal, Humanized
Antineoplastic Combined Chemotherapy Protocols--administration & dosage
Capecitabine
Cetuximab
Chemoradiotherapy, Adjuvant--methods
Colectomy--methods
Combined Modality Therapy
Deoxycytidine--administration & dosage
Disease-Free Survival
Female
Fluorouracil--administration & dosage
Follow-Up Studies
Humans
Intestinal Mucosa--surgery
Kaplan-Meier Estimate
Logistic Models
Male
Middle Aged
Neoadjuvant Therapy--methods
Neoplasm Invasiveness--pathology
Neoplasm Staging
Organoplatinum Compounds--administration & dosage
Oxaliplatin
Preoperative Care--methods
Radiotherapy, Adjuvant
Rectal Neoplasms--mortality
Risk Assessment
Survival Analysis
Treatment Outcome
United Kingdom