Detection of allosteric kinase inhibitors by displacement of active site probes.
Lebakken, Connie S
Detection of allosteric kinase inhibitors by displacement of active site probes. [electronic resource] - Journal of biomolecular screening Jul 2012 - 813-21 p. digital
Publication Type: Evaluation Study; Journal Article; Research Support, Non-U.S. Gov't
1552-454X
10.1177/1087057112439889 doi
Adenosine Triphosphate--metabolism
Allosteric Regulation--drug effects
Binding, Competitive
Catalytic Domain--drug effects
Drug Evaluation, Preclinical--methods
Fluorescence Resonance Energy Transfer
Fusion Proteins, bcr-abl--antagonists & inhibitors
Humans
Inhibitory Concentration 50
MAP Kinase Kinase 1--antagonists & inhibitors
Protein Binding
Protein Kinase Inhibitors--chemistry
Protein-Tyrosine Kinases--antagonists & inhibitors
Detection of allosteric kinase inhibitors by displacement of active site probes. [electronic resource] - Journal of biomolecular screening Jul 2012 - 813-21 p. digital
Publication Type: Evaluation Study; Journal Article; Research Support, Non-U.S. Gov't
1552-454X
10.1177/1087057112439889 doi
Adenosine Triphosphate--metabolism
Allosteric Regulation--drug effects
Binding, Competitive
Catalytic Domain--drug effects
Drug Evaluation, Preclinical--methods
Fluorescence Resonance Energy Transfer
Fusion Proteins, bcr-abl--antagonists & inhibitors
Humans
Inhibitory Concentration 50
MAP Kinase Kinase 1--antagonists & inhibitors
Protein Binding
Protein Kinase Inhibitors--chemistry
Protein-Tyrosine Kinases--antagonists & inhibitors