NK cells from HCV-infected patients effectively induce apoptosis of activated primary human hepatic stellate cells in a TRAIL-, FasL- and NKG2D-dependent manner.

Glässner, Andreas

NK cells from HCV-infected patients effectively induce apoptosis of activated primary human hepatic stellate cells in a TRAIL-, FasL- and NKG2D-dependent manner. [electronic resource] - Laboratory investigation; a journal of technical methods and pathology Jul 2012 - 967-77 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1530-0307

10.1038/labinvest.2012.54 doi


Adult
Aged
Aged, 80 and over
Antiviral Agents--administration & dosage
Apoptosis--physiology
Case-Control Studies
Fas Ligand Protein--physiology
Female
Hepatic Stellate Cells--pathology
Hepatitis C, Chronic--drug therapy
Humans
In Vitro Techniques
Interferon-alpha--administration & dosage
Interferon-gamma--biosynthesis
Killer Cells, Natural--immunology
Male
Middle Aged
NK Cell Lectin-Like Receptor Subfamily K--physiology
Polyethylene Glycols--administration & dosage
Recombinant Proteins--administration & dosage
Ribavirin--supply & distribution
TNF-Related Apoptosis-Inducing Ligand--physiology
Tumor Necrosis Factor-alpha--biosynthesis