Sulforaphane inhibits pancreatic cancer through disrupting Hsp90-p50(Cdc37) complex and direct interactions with amino acids residues of Hsp90.

Li, Yanyan

Sulforaphane inhibits pancreatic cancer through disrupting Hsp90-p50(Cdc37) complex and direct interactions with amino acids residues of Hsp90. [electronic resource] - The Journal of nutritional biochemistry Dec 2012 - 1617-26 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1873-4847

10.1016/j.jnutbio.2011.11.004 doi


Adenosine Triphosphate--metabolism
Animals
Antineoplastic Agents, Phytogenic--pharmacology
Binding Sites
Cell Cycle Proteins--metabolism
Cell Line, Tumor--drug effects
Chaperonins--metabolism
Female
HSP90 Heat-Shock Proteins--chemistry
Humans
Isothiocyanates
Magnetic Resonance Spectroscopy
Mice
Mice, Nude
Molecular Chaperones--metabolism
Pancreatic Neoplasms--drug therapy
Proteasome Endopeptidase Complex--metabolism
Protein Conformation
Sulfoxides
Thiocyanates--pharmacology
Xenograft Model Antitumor Assays