Presynaptically localized cyclic GMP-dependent protein kinase 1 is a key determinant of spinal synaptic potentiation and pain hypersensitivity.

Luo, Ceng

Presynaptically localized cyclic GMP-dependent protein kinase 1 is a key determinant of spinal synaptic potentiation and pain hypersensitivity. [electronic resource] - PLoS biology 2012 - e1001283 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1545-7885

10.1371/journal.pbio.1001283 doi


Aminoquinolines--pharmacology
Animals
Behavior, Animal
Cell Adhesion Molecules--genetics
Cyclic GMP-Dependent Protein Kinase Type I
Cyclic GMP-Dependent Protein Kinases--genetics
Enzyme Activation
Ganglia, Spinal--metabolism
Gene Deletion
Guanylate Cyclase--antagonists & inhibitors
Inositol 1,4,5-Trisphosphate Receptors--genetics
Long-Term Potentiation
Mice
Mice, Inbred C57BL
Mice, Knockout
Microfilament Proteins--genetics
Nerve Fibers--metabolism
Nociceptors--drug effects
Pain--metabolism
Patch-Clamp Techniques
Phosphoproteins--genetics
Phosphorylation
Signal Transduction
Substrate Specificity
Synaptic Transmission
Vasodilator-Stimulated Phosphoprotein