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Synthesis and in vitro evaluation of novel lipophilic monophosphorylated gemcitabine derivatives and their nanoparticles.

Lansakara-P, Dharmika S P

Synthesis and in vitro evaluation of novel lipophilic monophosphorylated gemcitabine derivatives and their nanoparticles. [electronic resource] - International journal of pharmaceutics Jun 2012 - 123-34 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural

ISSN: 1873-3476

Standard No.: 10.1016/j.ijpharm.2012.03.014 doi

Subjects--Topical Terms:
Animals
Antimetabolites, Antineoplastic--chemical synthesis
Cell Line, Tumor
Deoxycytidine--analogs & derivatives
Deoxycytidine Kinase--genetics
Drug Resistance, Neoplasm
Drug Screening Assays, Antitumor
Equilibrative Nucleoside Transporter 1--genetics
Gene Expression Regulation, Neoplastic
Humans
Lipids--chemistry
Mice
Nanoparticles
Neoplasms--drug therapy
Ribonucleoside Diphosphate Reductase--genetics
Tumor Suppressor Proteins--genetics
Gemcitabine