Anticancer drugs cause release of exosomes with heat shock proteins from human hepatocellular carcinoma cells that elicit effective natural killer cell antitumor responses in vitro.

Lv, Li-Hong

Anticancer drugs cause release of exosomes with heat shock proteins from human hepatocellular carcinoma cells that elicit effective natural killer cell antitumor responses in vitro. [electronic resource] - The Journal of biological chemistry May 2012 - 15874-85 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1083-351X

10.1074/jbc.M112.340588 doi


Antineoplastic Agents--pharmacology
Blotting, Western
Carcinoma, Hepatocellular--immunology
Cell Line, Tumor
Cell Survival--drug effects
Cells, Cultured
Chaperonin 60--immunology
Coculture Techniques
Cytotoxicity, Immunologic--immunology
Dose-Response Relationship, Drug
Exosomes--drug effects
Granzymes--immunology
HSP70 Heat-Shock Proteins--immunology
HSP90 Heat-Shock Proteins--immunology
Heat-Shock Proteins--immunology
Hep G2 Cells
Hot Temperature
Humans
K562 Cells
Killer Cells, Natural--immunology
Liver Neoplasms--immunology
NK Cell Lectin-Like Receptor Subfamily D--immunology