Aptamers as a sensitive tool to detect subtle modifications in therapeutic proteins.

Zichel, Ran

Aptamers as a sensitive tool to detect subtle modifications in therapeutic proteins. [electronic resource] - PloS one 2012 - e31948 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1932-6203

10.1371/journal.pone.0031948 doi


Animals
Antibodies, Monoclonal--chemistry
Aptamers, Peptide--chemistry
Biosensing Techniques
Cattle
Codon
Enzyme-Linked Immunosorbent Assay--methods
Epitopes--chemistry
Humans
Interferometry--methods
Kinetics
Protein Binding
Protein Conformation
Protein Processing, Post-Translational
Proteins--chemistry
Sensitivity and Specificity
Substrate Specificity
Temperature
Thrombin--chemistry