Short-acting P2Y12 blockade to reduce platelet dysfunction and coagulopathy during experimental extracorporeal circulation and hypothermia.

Krajewski, S

Short-acting P2Y12 blockade to reduce platelet dysfunction and coagulopathy during experimental extracorporeal circulation and hypothermia. [electronic resource] - British journal of anaesthesia Jun 2012 - 912-21 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1471-6771

10.1093/bja/aer518 doi


Adenosine Diphosphate--blood
Adenosine Monophosphate--analogs & derivatives
Animals
Antithrombin III--metabolism
Blood Coagulation Disorders--prevention & control
Blood Platelets--drug effects
Cardiopulmonary Bypass
Cytoplasmic Granules--drug effects
Extracorporeal Circulation
Humans
Hypothermia, Induced
Peptide Hydrolases--metabolism
Platelet Glycoprotein GPIIb-IIIa Complex--drug effects
Platelet Glycoprotein GPIb-IX Complex--analysis
Purinergic P2Y Receptor Antagonists--pharmacology
Swine