Protective and therapeutic efficacy of Mycobacterium smegmatis expressing HBHA-hIL12 fusion protein against Mycobacterium tuberculosis in mice.

Zhao, Shanmin

Protective and therapeutic efficacy of Mycobacterium smegmatis expressing HBHA-hIL12 fusion protein against Mycobacterium tuberculosis in mice. [electronic resource] - PloS one 2012 - e31908 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1932-6203

10.1371/journal.pone.0031908 doi


Animals
Antigens, Bacterial--immunology
Bacterial Proteins--pharmacology
Blotting, Western
Cloning, Molecular
Enzyme-Linked Immunospot Assay
Fluorescent Antibody Technique
Humans
Immunization
Interferon-gamma--immunology
Interleukin-12--pharmacology
Lung--drug effects
Membrane Proteins--pharmacology
Mice
Mycobacterium smegmatis--drug effects
Mycobacterium tuberculosis--drug effects
Phenotype
Protective Agents--pharmacology
Recombinant Fusion Proteins--pharmacology
Recombination, Genetic--drug effects
Spleen--drug effects
Th1 Cells--drug effects
Treatment Outcome
Tuberculosis--blood
Tuberculosis Vaccines--administration & dosage